Tennessee at Indianapolis - The Colts have struggled at times this season. But the Titans are really struggling and desperately want to earn their first win of the season. They have a chance at exposing the vulnerabilities that the Colts sometimes show. However, expect Indy to play well and likely earn a win here in this one.. My pick: Indianapolis
Chicago at Atlanta - This is a tougher game than it might at first appear. Either team could conceivably earn a win in this one. However, the Bears have struggled following that stunning 59 point season opener, while the Falcons have played tough in recent weeks, especially at home. That's why I'm going with the home team. My pick: Atlanta
Carolina at Philadelphia - Believe it or not, I suspect that Carolina will make a real game of this. Philly dropped from an impressive 2-0 start to losing three straight and now ranking as a losing team. Still, they are at home and coming off a stunning loss last weekend. This is a test of how they respond. My suspicion is that they find a way to win this one. My pick: Philly
Baltimore at Cleveland - Lamar Jackson will not be playing in this one. That still makes this a tough game, because the Ravens have been playing so well. Still, the Browns are coming off a tough loss, but should play better at home. Also, they simply cannot afford to lose this one and allow the Ravens to open up a two-game lead. My pick: Cleveland
Pittsburgh at Tampa Bay - The Bucs finally earned a win last week. But the Steelers are tough and have a lot to play for right now. My suspicion is that the Steelers find a way to win this one. My pick: Pittsburgh
Arizona at LA Rams - Both the Rams and the Cardinals are struggling. However, the Rams clearly are a very talented team with realistic playoff hopes, possibly even title hopes. Their offense is dynamic and can be very dangerous and explosive. Also, they are desperately in need of a win. And the Cardinals have possibly the worst defense in the league and are in a serious rut. This one feels like a no-brainer. My pick: LA Rams
Buffalo at Las Vegas - The Raiders raced out to a 3-0 start and looked impressive. But now they have dropped two straight and host a very tough Bills team. The Bills look solid again and need a win to stay ahead of the Pats in the AFC East. They should earn a solid road win here. My pick: Buffalo
LA Chargers at Kansas City - An undefeated Chiefs team hosting a winless Chargers team. On paper, it should be a relatively easy win for KC. However, keep in mind that these two teams have familiarity with each other, which gives the Chargers a shot. Still, the way that things have been going this season, it would be madness to pick the Chargers or pick against the Chiefs in this one. My pick: Kansas City
Sunday Night Football: Dallas at Green Bay - Remember when this was possibly the key rivalry in football? Well, not anymore. Yet, both teams have realistic expectations of contending for the postseason. Only one team can win, although neither can afford to lose more ground within their division. Lambeau Field is always a tough place to play for road teams, and that is a factor. My pick: Green Bay
Monday Night Football: Washington at San Francisco 49ers - The 49ers are 5-0 right now. They have gotten off to impressive unbeaten starts under Shanahan before. Both prior times, they went to the Super Bowl. It feels like this 49ers team is that good, as well. They should have enough to get past a Washington team still stunned from the end of last week's game, where they were harshly criticized for poor clock management costing them a win.. My pick: San Francisco

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